[Current views on the development of diabetic retinopathy].

  • Sosna T
  • 2


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


The basic pathogenic mechanism of the diabetic retinopathy is hyperglycaemia. Capillary damage could be explained by several mechanisms. Among many causes the sorbitol overload, the excessive storage of advanced glycosylation endproducts, oxidative stress and/or the cell apoptosis after the paradoxical glucose starvation can be emphasised. The article further analyses mechanism of capillary damage in the retina is on the basis of hemorheological, hemodynamical and histopathological changes. The specific role of the retinal pigment epithelium is described. Histopathological changes accompanying the elementary microcirculatory anomalies result from the apoptotic death of pericytes, damage of endothelial cells, and impairment of the basal membrane. Microcirculatory changes, which include the capillary dilation, vascular occlusion, and proliferation of new vessels, bring about further development of the diabetic retinopathy.

Author-supplied keywords

  • Capillaries
  • Capillaries: physiopathology
  • Diabetic Retinopathy
  • Diabetic Retinopathy: etiology
  • Diabetic Retinopathy: pathology
  • Diabetic Retinopathy: physiopathology
  • Humans
  • Hyperglycemia
  • Hyperglycemia: complications
  • Hyperglycemia: physiopathology
  • Pigment Epithelium of Eye
  • Pigment Epithelium of Eye: physiopathology
  • Retinal Vessels
  • Retinal Vessels: pathology
  • Retinal Vessels: physiopathology

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • T Sosna

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free