Cyclooxygenase-2: a therapeutic target.

  • Turini M
  • DuBois R
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Abstract

Cyclooxygenase (COX), also known as prostaglandin endoperoxide synthase, is the key enzyme required for the conversion of arachidonic acid to prostaglandins. Two COX isoforms have been identified, COX-1 and COX-2. In many situations, the COX-1 enzyme is produced constitutively (e.g., in gastric mucosa), whereas COX-2 is highly inducible (e.g., at sites of inflammation and cancer). Traditional nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both enzymes, and a new class of COX-2 selective inhibitors (COXIBs) preferentially inhibit the COX-2 enzyme. This review summarizes our current understanding of the role of COX-1 and COX-2 in normal physiology and disease.

Author-supplied keywords

  • Anti-Inflammatory Agents
  • Clinical Trials as Topic
  • Cyclooxygenase 1
  • Cyclooxygenase 2
  • Cyclooxygenase 2 Inhibitors
  • Cyclooxygenase Inhibitors
  • Cyclooxygenase Inhibitors: adverse effects
  • Cyclooxygenase Inhibitors: therapeutic use
  • Humans
  • Inflammation
  • Inflammation: drug therapy
  • Inflammation: enzymology
  • Isoenzymes
  • Isoenzymes: antagonists & inhibitors
  • Membrane Proteins
  • Neoplasms
  • Neoplasms: drug therapy
  • Neoplasms: enzymology
  • Non-Steroidal
  • Non-Steroidal: adverse e
  • Non-Steroidal: therapeut
  • Prostaglandin-Endoperoxide Synthases

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Authors

  • Marco E Turini

  • Raymond N DuBois

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