Cyclophilin inhibitors

  • Flisiak R
  • Parfieniuk-Kowerda A
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Abstract

The percentage of patients chronically infected with hepatitis C virus (HCV) who have reached sustained antiviral response has increased since the introduction of the pegylated interferon-alpha (pIFNa) and ribavirin (RBV) treatment. However, the current standard pIFNa/RBV therapy not only has a low success rate (about 50%) but is often associated with serious side effects. Thus, there is an urgent need for the development of new anti-HCV agents. Cyclophilin (Cyp) inhibitors are among the most promising of the new anti-HCV agents under development. Recent clinical studies demonstrate that Cyp inhibitors are potent anti-HCV drugs, with a novel mechanism of action and efficacy profiles that make them attractive candidates for combination with current and future HCV treatments. © 2009 Elsevier Inc. All rights reserved.

Author-supplied keywords

  • Alisporivir
  • Cyclosporine
  • Debio-025
  • Host targeting antivirals
  • Liver
  • NIM-811
  • SCY-635
  • Viral hepatitis

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