CYP1A1 gene polymorphisms increase lung cancer risk in a high - incidence region of Spain : a case control study

  • San Jose C
  • Cabanillas A
  • Benitez J
 et al. 
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Abstract

See, stats, and : https : / / www . researchgate. net / publication / 46094562 CYP1A1 cancer - incidence : A Article DOI : 10 . 1186 / 1471 - 2407 - 10 - 463 : PubMed CITATIONS 21 READS 43 6 , including : Carmen Hospital 5 SEE Julio Universidad 127 , 058 SEE Guillermo Universidad 77 , 234 SEE All - text , letting . Available : Guillermo Retrieved : 28 Abstract Background :Aruralregioninsouth-westSpainhasoneofthehighestlungcancerincidenceratesofthecountry,asrevealedbyapreviousepidemiological10-yearfollow-upstudy.ThepresentworkwasundertakentoascertaintheroleofCYP1A1genepolymorphismsandtheirinteractionwithtobaccosmokinginthedevelopmentofthediseaseinthislocation.Methods:One-hundred-and-threecasesoflungcancerand265controlsparticipatedinthestudy.TheparticipantswerescreenedforthepresenceoffourCYP1A1polymorphisms,namelyMspI,Ile462Val,T3205C,andThr461Asn.Lungcancerriskwasestimatedasoddsratios(OR)and95%confidenceintervals(CI)usingunconditionallogisticregressionmodelsadjustingforage,sex,andsmoking.Results:ThedistributionofthevariantCYP1A1alleleswasdifferentfromthatdescribedforotherCaucasianpopulations,withCYP1A1*2Ashowinganuncommonlyhighfrequency(p

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Authors

  • Carmen San Jose

  • Agustin Cabanillas

  • Julio Benitez

  • Juan Antonio Carrillo

  • Mercedes Jimenez

  • Guillermo Gervasini

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