Cytokines and C-reactive protein production in hip-fracture-operated elderly patients

  • Beloosesky Y
  • Hendel D
  • Weiss A
 et al. 
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BACKGROUND The study aim was to determine the kinetics of serum pro- and anti-inflammatory cytokines and C-reactive protein (CRP) in hip-fracture patients over a month postfracture, and their relationship to postoperative (postop) complications and cognitive level. METHODS Forty-one elderly hip-fracture patients were prospectively followed. Serum was obtained during the first 10 hours postfracture and presurgery, 48-60 hours postop, 7 and 30 days postop, measuring CRP, interleukin-1beta (IL-1beta), IL-6, IL-8, tumor necrosis factor-alpha (TNF-alpha), IL-10, and IL-1 receptor antagonist (IL-1RA). RESULTS A significant increase was found postop for CRP, IL-6, TNF-alpha, IL-1RA (p

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  • Yichayaou Beloosesky

  • David Hendel

  • Avraham Weiss

  • Avital Hershkovitz

  • Joseph Grinblat

  • Anatoly Pirotsky

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