Journal article

Cytotoxic constituents from Podocarpus fasciculus.

Kuo Y, Hwang S, Wu M, Liao C, Liang Y, Ho H, Uo Y, Wang S, Ming-der W, Iao C, Iang Y ...see all

Chemical & pharmaceutical bulletin, vol. 56, issue 4 (2008) p. 585–8

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A new diterpene, 16-hydroxy communic acid (1), along with thirty one known compounds including five norditerpenes (2-6), twenty two flavonoids containing four biflavonoids (7-10), nine monoflavonoids (11-19) and nine flavanoid glycosides (20-28), as well as four phenolic constituents (29-32) were isolated from the 95% ethanolic extract of Podocarpus fasciculus. The structure of 1 was elucidated using spectral methods. Of these isolates, nagilactone C (2) showed the most significant inhibitory effects against DLD cells (human colon carcinoma) (ED(50)=2.57 microg/ml) and compounds 7, 8, 10, 11, and 12 had moderate cytotoxic activity against human KB (human oral epithelium carcinoma), Hela (human cervical carcinoma), Hepa (human hepatoma), DLD (colon carcinoma), and A-549 (human lung carcinoma) tumor cell lines. Preliminary structure-activity relationship studies of the isolated diterpenoids and biflavonoids are discussed.

Author-supplied keywords

  • 16-hydroxy communic acid
  • cytotoxic activity
  • podocarpaceae
  • podocarpus fasciculus

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  • Yu-Jen Yao-Haur Kuo

  • Shy-Yuan Hwang

  • Ming-Der Wu

  • Chia-Ching Liao

  • Yu-Han Liang

  • Hsiu-O Ho

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