Cytotoxic indole alkaloids from Tabernaemontana officinalis

  • Zhang B
  • Teng X
  • Bao M
 et al. 
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Abstract

Continued interest in cytotoxic alkaloids resulted in the isolation of 37 alkaloids including 29 known monoterpenoid indole alkaloids from the aerial parts of Tabernaemontana officinalis. Of the remaining 8 alkaloids, six were bisindole alkaloids named taberdivarines A-F (1-6) and the two were monomers named taberdivarines G and H (7-8). Alkaloids 1 and 2 are voaphylline-vobasinyl type bisindole alkaloids, a structural type previously unknown, while 3-6 exhibited cytotoxicity against three human cancer cell lines HeLa, MCF-7, and SW480 with IC50values ranging from 1.42 to 11.35 μM.

Author-supplied keywords

  • Apocynaceae
  • Bisindole alkaloid
  • Cytotoxicity
  • Monoterpenoid indole alkaloid
  • Tabernaemontana officinalis

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