The dachshund gene is required for the proper guidance and branching of mushroom body axons in Drosophila melanogaster

  • Martini S
  • Davis R
  • 33

    Readers

    Mendeley users who have this article in their library.
  • 12

    Citations

    Citations of this article.

Abstract

The dachshund gene encodes a transcription factor required for the proper development of Drosophila eyes, legs, and mushroom bodies. The mushroom bodies of dachshund mutants exhibit a marked reduction in the size of the vertical lobes and disorganization of the horizontal lobes. In mosaic animals, mutant axons fail to contribute significantly to the mushroom body alpha lobe. Here we show that this defect is due to the misrouting of alphabeta axons to the region normally occupied by alpha'beta' axons. This defect is pronounced for clones generated in larval stages but not clones generated after pupariation, indicating that dachshund function is particularly important around the time of puparium formation. In addition, mushroom body axons exhibit excessive branching in dachshund mutant clones. Thus, dachshund is required in mushroom body neurons for proper axon guidance and branching.

Author-supplied keywords

  • Axon branching
  • Axon guidance
  • Dachshund
  • Drosophila
  • Mushroom body

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text

Authors

  • Sharyl R. Martini

  • Ronald L. Davis

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free