Decreasing sleep-time blood pressure determined by ambulatory monitoring reduces cardiovascular risk

  • Hermida R
  • Ayala D
  • Mojón A
 et al. 
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Objectives: We investigated whether reduced cardiovascular risk is more related to the progressive decrease of asleep or awake blood pressure. Background: Independent studies have concluded that elevated sleep-time blood pressure is a better predictor of cardiovascular risk than awake or 24-h blood pressure means. However, the impact on cardiovascular risk of changes in these ambulatory blood pressure characteristics has not been properly investigated. Methods: We prospectively studied 3,344 subjects (1,718 men and 1,626 women), 52.6 ± 14.5 years of age, during a median follow-up of 5.6 years. Those with hypertension at baseline were randomized to ingest all their prescribed hypertension medications upon awakening or

Author-supplied keywords

  • ambulatory blood pressure monitoring
  • cardiovascular risk
  • chronotherapy
  • hypertension
  • sleep-time relative blood pressure decline

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