Deep brain stimulation for gait and postural symptoms in Parkinson's disease

  • M. P
  • J. V
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Abstract

In patients with Parkinson's disease, gait and balance difficulties have emerged as some of the main therapeutic concerns. During earlier stages of the disease, the dopamine-responsive aspects of gait disorder can be treated initially with dopaminergic drugs or deep brain stimulation. However, certain temporal aspects of parkinsonian gait disorder remain therapeutically resistant in both the short term and the long term. In this review, we summarize the effects of deep brain stimulation on gait and postural symptoms in the five currently available targets (subthalamic nucleus, globus pallidus, ventralis intermedius thalamic nucleus, pedunculopontine nucleus, and substantia nigra) and describe programming strategies for patients who are mainly disabled by gait problems. (copyright) 2013 Movement Disorder Society.

Author-supplied keywords

  • Berg Balance Scale
  • Parkinson disease
  • REM sleep
  • Unified Parkinson Disease Rating Scale
  • abnormal posture
  • akinesia
  • alertness
  • brain depth stimulation
  • cerebellum
  • cognitive defect
  • daily life activity
  • depth electrode
  • electrode implant
  • follow up
  • frequency modulation
  • gait disorder
  • globus pallidus
  • hypokinesia
  • levodopa
  • limb disease
  • meta analysis (topic)
  • multicenter study (topic)
  • muscle rigidity
  • nonREM sleep
  • nuclear magnetic resonance imaging
  • pedunculopontine tegmental nucleus
  • priority journal
  • quality of life
  • randomized controlled trial (topic)
  • response time
  • review
  • sleep
  • spatiotemporal analysis
  • substantia nigra
  • subthalamic nucleus
  • systematic review (topic)
  • tremor
  • walking speed
  • working memory

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Authors

  • Potter-Nerger M.

  • Volkmann J.

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