Defective CD8 T cell memory following acute infection without CD4 T cell help

  • Sun J
  • Bevan M
  • 43


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The CD8(+) cytotoxic T cell response to pathogens is thought to be CD4(+) helper T cell independent because infectious agents provide their own inflammatory signals. Mice that lack CD4(+) T cells mount a primary CD8 response to Listeria monocytogenes equal to that of wild-type mice and rapidly clear the infection. However, protective memory to a challenge is gradually lost in the former animals. Memory CD8(+) T cells from normal mice can respond rapidly, but memory CD8(+) T cells that are generated without CD4 help are defective in their ability to respond to secondary encounters with antigen. The results highlight a previously undescribed role for CD4 help in promoting protective CD8 memory development.

Author-supplied keywords

  • ective cd8 t cell
  • memory following acute infection
  • without cd4

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  • J C Sun

  • M J Bevan

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