Denhaminols A-H, Dihydro-β-agarofurans from the Endemic Australian Rainforest Plant Denhamia celastroides

  • Levrier C
  • Sadowski M
  • Nelson C
 et al. 
  • 45


    Mendeley users who have this article in their library.
  • 9


    Citations of this article.


Eight new dihydro-β-agarofurans, denhaminols A−H(1−8), were isolated from the leaves of the Australian rainforest tree Denhamia celastroides. The chemical structures of 1−8 were elucidated following analysis of 1D/2D NMR and MS data. The absolute configuration of denhaminol A (1) was determined by single-crystal X-ray crystallography. All compounds were evaluated for cytotoxic activity against the human prostate cancer cell line LNCaP, using live-cell imaging and metabolic assays. Denhaminols A (1) and G (7) were also tested for their effects on the lipid content of LNCaP cells. This is the first report of secondary metabolites from D. celastroides.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free