Density gradients at hydrogel interfaces for enhanced cell penetration

  • Simona B
  • Hirt L
  • Demk?? L
 et al. 
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Abstract

We report that stiffness gradients facilitate infiltration of cells through otherwise cell-impermeable hydrogel interfaces. By enabling the separation of hydrogel manufacturing and cell seeding, and by improving cell colonization of additively manufactured hydrogel elements, interfacial density gradients present a promising strategy to progress in the creation of 3D tissue models.

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