We report that stiffness gradients facilitate infiltration of cells through otherwise cell-impermeable hydrogel interfaces. By enabling the separation of hydrogel manufacturing and cell seeding, and by improving cell colonization of additively manufactured hydrogel elements, interfacial density gradients present a promising strategy to progress in the creation of 3D tissue models.
CITATION STYLE
Simona, B. R., Hirt, L., Demkó, L., Zambelli, T., Vörös, J., Ehrbar, M., & Milleret, V. (2015). Density gradients at hydrogel interfaces for enhanced cell penetration. Biomaterials Science, 3(4), 586–591. https://doi.org/10.1039/c4bm00416g
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