Dependence of self-tolerance on TRAF6-directed development of thymic stroma

  • Akiyama T
  • Maeda S
  • Yamane S
 et al. 
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Abstract

The microenvironments of the thymus are generated by thymic epithelial cells (TECs) and are essential for inducing immune self-tolerance or developing T cells. However, the molecular mechanisms that underlie the differentiation of TECs and thymic compartmentalization are not fully understood. Here we show that deficiency in the tumor necrosis factor receptor-associated factor (TRAF) 6 results in disorganized distribution of medullary TECs (mTECs) and the absence of mature mTECs. Engraftment of thymic stroma of TRAF6(-/-) embryos into athymic nude mice induced autoimmunity. Thus, TRAF6 directs the development of thymic stroma and represents a critical point of regulation for self-tolerance and autoimmunity.

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Authors

  • Taishin Akiyama

  • Shiori Maeda

  • Sayaka Yamane

  • Kaori Ogino

  • Michiyuki Kasai

  • Fumiko Kajiura

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