Depressive symptoms are associated with fasting insulin resistance in obese youth

  • Hannon T
  • Li Z
  • Tu W
 et al. 
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BACKGROUND: In adults, depressive symptoms are positively associated with insulin resistance. OBJECTIVE: To determine whether an association exists between depressive symptoms and markers of insulin resistance in youth. METHODS: This study used a retrospective review of data from an obesity clinic. We evaluated the association between depressive symptoms (Children's Depression Inventory, CDI) and fasting insulin and homeostatic model assessment-insulin resistance (HOMA-IR) in obese youth (n = 207, age 10-18 years). Individuals with lower vs. higher CDI T-scores (/=65) were compared; this cut-point is accepted as indicating the possibility of clinical depression. Multiple linear regression was used to evaluate relationships between CDI T-scores and insulin resistance. RESULTS: Fasting insulin and HOMA-IR values were 40% higher in patients with higher CDI T-scores (P = 0.04). After accounting for gender, race, age and body mass index, CDI T-score remained associated with HOMA-IR, although the strength of the association was small (b = 0.007, P = 0.049). CONCLUSIONS: Relationships between depressive symptoms and insulin resistance should be considered when evaluating obese youth.

Author-supplied keywords

  • *Insulin Resistance
  • Adolescent
  • Age Distribution
  • Blood Glucose/*metabolism
  • Body Mass Index
  • Child
  • Depression/blood/etiology/*metabolism
  • Fasting
  • Female
  • Humans
  • Male
  • Pediatric Obesity/blood/complications/*metabolism/
  • Retrospective Studies
  • Risk Assessment
  • Severity of Illness Index
  • Sex Distribution
  • depression
  • insulin sensitivity
  • overweight

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  • T S Hannon

  • Z Li

  • W Tu

  • J N Huber

  • A E Carroll

  • A M Lagges

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