Depth-resolved imaging of functional activation in the rat cerebral cortex using optical coherence tomography.

  • Aguirre A
  • Chen Y
  • Fujimoto J
 et al. 
  • 24

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Abstract

Co-registered optical coherence tomography (OCT) and video microscopy of the rat somatosensory cortex were acquired simultaneously through a thinned skull during forepaw electrical stimulation. Fractional signal change measured by OCT revealed a functional signal time course corresponding to the hemodynamic signal measurement made with video microscopy. OCT can provide high-resolution, cross-sectional images of functional neurovascular activation and may offer a new tool for basic neuroscience research in the important rat cerebral cortex model.

Author-supplied keywords

  • Animals
  • Brain Mapping
  • Brain Mapping: methods
  • Cerebral Cortex
  • Cerebral Cortex: physiology
  • Computer-Assisted
  • Computer-Assisted: instrumen
  • Computer-Assisted: methods
  • Equipment Design
  • Equipment Failure Analysis
  • Image Interpretation
  • Microscopy
  • Optical Coherence
  • Optical Coherence: instrumentation
  • Optical Coherence: methods
  • Rats
  • Tomography
  • Video
  • Video: instrumentation
  • Video: methods

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Authors

  • Aaron D Aguirre

  • Y Chen

  • J G Fujimoto

  • L Ruvinskaya

  • a Devor

  • D a Boas

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