Depth-resolved imaging of functional activation in the rat cerebral cortex using optical coherence tomography

  • Devor A
  • Aguirre A
  • Fujimoto J
 et al. 
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Abstract

Co-registered optical coherence tomography (OCT) and video microscopy of the rat somatosensory cortex were acquired simultaneously through a thinned skull during forepaw electrical stimulation. Fractional signal change measured by OCT revealed a functional signal time course corresponding to the hemodynamic signal measurement made with video microscopy. OCT can provide high-resolution, cross-sectional images of functional neurovascular activation and may offer a new tool for basic neuroscience research in the important rat cerebral cortex model.

Author-supplied keywords

  • *Brain Mapping
  • Animals
  • Equipment Design
  • Equipment Failure Analysis
  • MID - NIHMS43990
  • Methods
  • Microscopy: Video
  • OID - NLM: NIHMS43990
  • OID - NLM: PMC2293976
  • PMC - PMC2293976
  • Physiology
  • Rats
  • Tomography: Optical Coherence
  • cerebral cortex
  • image interpretation computerassisted
  • instrumentation

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Authors

  • A Devor

  • A Aguirre

  • J Fujimoto

  • D Boas

  • Y Chen

  • L Ruvinskaya

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