A design principle for vascular beds: the effects of complex blood rheology

  • Alarcón T
  • Byrne H
  • Maini P
  • 1


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


We propose a design principle that extends Murray's original optimization principle for vascular architecture to account for complex blood rheology. Minimization of an energy dissipation function enables us to determine how rheology affects the morphology of simple branching networks. The behavior of various physical quantities associated with the networks, such as the wall shear stress and the flow velocity, is also determined. Our results are shown to be qualitatively and quantitatively compatible with independent experimental observations and simulations.

Author-supplied keywords

  • Blood Circulation Time
  • Blood Flow Velocity/ physiology
  • Capillaries/physiology
  • Hemorheology
  • Models, Cardiovascular
  • Stress, Mechanical

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in


  • T Alarcón

  • H M Byrne

  • P K Maini

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free