Detailed molecular dynamics simulations of model biological membranes containing cholesterol

  • Berkowitz M
  • 1

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

Detailed molecular dynamics simulations performed to study the nature of lipid raft domains that appear in model membranes are reviewed in this paper. The described simulations were performed on hydrated bilayers containing binary mixtures of cholesterol with phospholipids and also on ternary mixtures containing cholesterol, a phospholipid with a high main transition temperature T-m, and a phospholipid with a low transition temperature Tm. These simulations provide qualitative and semi-quantitative information about cholesterol-lipid interactions and also a testing ground for major assumptions made to explain the nature of lipid rafts in model membranes. (C) 2008 Elsevier B.V. All rights reserved.

Author-supplied keywords

  • Cell-Membranes
  • Cholesterol--lipid complex
  • Cholesterol--lipid interaction
  • Cholesterol-Lipid Complex
  • Cholesterol-Lipid Interaction
  • Computer simulations of lipid bilayer
  • Condensed Complexes
  • Constant-Pressure
  • Dipalmitoylphosphatidylcholine Bilayer
  • Domain Formation
  • Lipid raft
  • Lipid-Bilayers
  • Model biological membrane
  • Molecular dynamics of lipid
  • Monte-Carlo Simulations
  • Phase-Behavior
  • Phosphatidylcholine Bilayer
  • Phospholipid-Membranes

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Max L Berkowitz

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free