Detection of cell-affecting agents with a silicon biosensor

  • Parce J
  • Owicki J
  • Kercso K
 et al. 
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Abstract

Cellular metabolism is affected by many factors in a cell's environment. Given a sufficiently sensitive method for measuring cellular metabolic rates, it should be possible to detect a wide variety of chemical and physical stimuli. A biosensor has been constructed in which living cells are confined to a flow chamber in which a potentiometric sensor continually measures the rate of production of acidic metabolites. Exploratory studies demonstrate several applications of the device in basic science and technology.

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Authors

  • J. Wallace Parce

  • John C. Owicki

  • Karen M. Kercso

  • George B. Sigal

  • H. G. Wada

  • Victoria C. Muir

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