Detection of gliotoxin in experimental and human aspergillosis

  • Lewis R
  • Wiederhold N
  • Chi J
 et al. 
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Abstract

Gliotoxin was measured in the lungs (mean, 3,976 +/- 1,662 ng/g of tissue) and sera (mean, 36.5 +/- 30.28 ng/ml) of mice with experimentally induced invasive aspergillosis (IA), and levels decreased with antifungal therapy. Gliotoxin could also be detected in the sera of cancer patients with documented (proven or probable) IA.

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