Detection of low levels of human immunodeficiency virus (HIV) may be critical for early diagnosis of pediatric HIV infection by use of dried blood spots

  • J. W
  • L. K
  • K. S
 et al. 
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Abstract

We compared a DNA-based assay with a total nucleic acid-based assay for early detection of infant human immunodeficiency virus (HIV) infection. The codetection of DNA and RNA did not result in an overall higher sensitivity compared to that of DNA alone. Discordant results were associated with low levels of HIV DNA, indicating that the sample amount may be critical. Copyright (copyright) 2009, American Society for Microbiology. All Rights Reserved.

Author-supplied keywords

  • DNA determination
  • Human immunodeficiency virus infection
  • article
  • assay
  • blood
  • childhood disease
  • early diagnosis
  • human
  • infant
  • intermethod comparison
  • major clinical study
  • nonhuman
  • nucleic acid
  • nucleic acid analysis
  • priority journal
  • virus DNA
  • virus RNA
  • virus detection

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Authors

  • Walter J.

  • Kuhn L.

  • Semrau K.

  • Decker D.W.

  • Sinkala M.

  • Kankasa C.

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