Determination of amoxicillin in plasma samples by capillary electrophoresis

  • Hernández M
  • Borrull F
  • Calull M
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Abstract

We have developed a capillary zone electrophoresis (CZE) method for determining amoxicillin in animal plasma samples. Sample clean-up involved solid-phase extraction onto Sep-Pak C18cartridges followed by elution with water-methanol (85:15). This paper describes two different techniques to increase the sensitivity of the CZE method: field-amplified sample injection (FASI) and electrokinetic injection. We have enhanced the detection limit to 280 μg l-1by the FASI technique. Copyright (C) 1999 Elsevier Science B.V.

Author-supplied keywords

  • Amoxicillin
  • Antibiotics
  • Injection methods
  • Solid-phase extraction

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