Development of neuropharmacologically based behavioral assessments of impulsive aggressive behavior.

  • Coccaro E
  • Harvey P
  • Kupsaw-Lawrence E
 et al. 
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Developed pharmacologically sensitive indices of impulsive aggressive behaviors that putatively arise from a deficit in central 5-hydroxytryptamine (5-HT) function. Ss were 22 adult patients with a primary Diagnostic and Statistical Manual of Mental Disorders (DSM-III) diagnosis of either personality disorder or major depressive disorder and 20 young adult controls. The choice of items for the self-rated assessment scale, designated the Anger, Irritability, Assault Questionnaire (AIAQ), was based on data obtained in a previously reported study by E. F. Coccaro et al (see record 1989-40083-001). Relevant subscales were adapted from the Buss-Durkee Hostility Inventory and Affect Lability Scale. The core items for a clinician rated assessment of impulsive aggression came from the Overt Aggression Scale (OAS) and was called the OAS modified (OAS-M). The data support the convergent validity of the AIAQ and the OAS-M.

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  • E F Coccaro

  • P D Harvey

  • E Kupsaw-Lawrence

  • J L Herbert

  • D P Bernstein

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