Development of non-viral vectors for systemic gene delivery

277Citations
Citations of this article
115Readers
Mendeley users who have this article in their library.
Get full text

Abstract

One of the major challenges for gene therapy is systemic delivery of a nucleic acid directly into an affected tissue. This requires developing a vehicle which is able to protect the nucleic acid from degradation, while delivering the gene of interest to the specific tissue and specific subcellular compartment. In this review, we summarize some of the recent advances in new non-viral delivery systems for systemic administration. Two types of gene delivery systems are described: (i) LPD1 (cationic liposome-entrapped, polycation-condensed DNA, type 1), and (ii) retention-time mediated naked DNA delivery. Hypothesized mechanisms for these systemic gene transfers are also discussed. © 2002 Elsevier Science B.V. All rights reserved.

Cite

CITATION STYLE

APA

Liu, F., & Huang, L. (2002). Development of non-viral vectors for systemic gene delivery. Journal of Controlled Release, 78(1–3), 259–266. https://doi.org/10.1016/S0168-3659(01)00494-1

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free