Development of a Production Process for Stem Cell Based Cell Therapeutic Implants Using Disposable Bioreactor Systems

  • Weber C
  • Pohl S
  • Poertner R
 et al. 
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Abstract

Cell therapy enables the treatment of various diseases like diabetes mellitus or stroke. The basis of many cell implants are mesenchymal stem cells, which have to be multiplied and harvested with high viability prior to use. For that purpose bioreactor systems are required, which allow the cultivation of the cells under GMP-conforming conditions. Here a fixed bed cultivation system for the expansion and differentiation of a hMSC production cell line on the basis of commercially available polymeric or glass syringes is introduced.

Author-supplied keywords

  • hMSC-TERT; fixed bed bioreactor; harvesting

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Authors

  • C Weber

  • S Pohl

  • R Poertner

  • C Wallrapp

  • P Geigle

  • P Czermak

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