Development of Self-Emulsifying Drug Delivery Systems (SEDDS) for Oral Bioavailability Enhancement of Poorly Soluble Drugs

  • Fatouros D
  • Müllertz A
  • 2

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

Summary: In this chapter we place into context the mechanisms guide the lipid processing and drug solubilisation in the gastrointestinal tract. We review the evolution of the scientific progress that underpins current research efforts towards the design of novel self- emulsifying drug delivery systems that will provide the means of facilitating the transport poorly soluble drugs, which in turn will increase their oral bioavailability. Finally we review the use of τhe dynamic lipolysis model as a readily accessible in vitro means of determining the behaviour of poorly soluble compounds under conditions simulating those of the GIT under fasted or fed conditions. This model uses bile salts, phospholipids and the generation of lipolysis products (LP) to reproduce the solubilising environment of the GIT. This edition first published 2013 © 2013 John Wiley & Sons, Ltd..

Author-supplied keywords

  • [In vitro digestion model, Lipolysis, Oral absorpt

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • D.G. Fatouros

  • A. Müllertz

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free