Development of Self-Emulsifying Drug Delivery Systems (SEDDS) for Oral Bioavailability Enhancement of Poorly Soluble Drugs

  • Fatouros D
  • Müllertz A
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A review. This article describes the development of self-emulsifying drug delivery systems for oral bioavailability enhancement of poorly sol. drugs. Liq. dosage forms such as self-emulsifying drug delivery systems (SEDDS), which rely on the use of lipid and surfactant excipients to dissolve the drug in the formulation, are thought to improve the bioavailability of poorly water sol. drugs by dosing the drug compd. in soln., thereby obviating the need for pre-absorptive dissoln. in the GlT. The presence of hydrophilic surfactants enables the formulation of a nanoemulsion that can keep the drug compd. in soln. for a prolonged period of time at the site of absorption for effective absorption, so pptn. of the drug compd. within the GI lumen is prevented unless it is in the amorphous state. The in vivo studies have clearly demonstrated the superiority of SEDDS and SMEDDS formulations over the non-self-dispersing lipid-based formulations. [on SciFinder(R)]

Author-supplied keywords

  • In vitro digestion model
  • Lipolysis
  • Oral absorption
  • Self-emulsifying drug delivery systems

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  • Dimitrios G. Fatouros

  • Anette Müllertz

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