Development of transmucosal patch using nanofibers

  • Grewal H
  • Dhakate S
  • Goyal A
 et al. 
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In the present work we have attempted to develop a novel transmucosal
patch of diclofenac sodium using electrospun polycaprolactone (PCL)
nanofibers. PCL nanofibers were prepared by electrospinning techniques
using different polymer concentrations. Nanofibers formulations were
characterized by SEM, FTIR, drug loading, and in-vitro release study
using Franz diffusion cell. Studies revealed the nanofibers fabricated
from 13% PCL were fracture-free, non-beaded, and ultrafine with 120 nm
diameter. Release studies demonstrated the sustained release behavior of
PCL nanofibers. Nanofibers can be exploited for transmucosal drug
delivery of NSAID with improved therapeutic efficacy.

Author-supplied keywords

  • Diclofenac sodium
  • Electrospinning
  • Nanofiber
  • Toothache

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  • Harleen Grewal

  • Sanjay R. Dhakate

  • Amit K. Goyal

  • Tanmay S. Markandeywar

  • Basant Malik

  • Goutam Rath

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