Device closure of paravalvular defects following transcatheter aortic valve replacement with the edwards sapien valve

  • Whisenant B
  • Jones K
  • Horton K
 et al. 
  • 4


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Paravalvular aortic insufficiency (AI) is observed in the majority of patients undergoing transcatheter aortic valve replacement (TAVR). While paravalvular AI is most commonly modest following TAVR, moderate or severe AI was seen in 10.5% and 6.8% of the PARTNER inoperable and high-risk cohorts at 1 year and has been reportedly associated with dyspnea and diminished survival. We report two cases of transcatheter heart valve (THV) associated paravalvular defects closed using catheter delivered devices. Both patients derived hemodynamic and symptomatic improvement from device closure. Additional research is warranted to define the adverse consequences of THV associated AI, indications for treatment, and risks associated with device closure of these defects. © 2012 Wiley Periodicals, Inc.

Author-supplied keywords

  • Flexor CheckFlow Introducer
  • New York Heart Association class
  • aged
  • aorta root
  • aorta valve disease
  • aorta valve regurgitation
  • article
  • case report
  • catheter
  • cohort analysis
  • disease association
  • disease severity
  • dyspnea
  • guide wire
  • heart ejection fraction
  • heart hemodynamics
  • high risk patient
  • human
  • male
  • percutaneous aortic valve
  • survival
  • transcatheter aortic valve implantation
  • transesophageal echocardiography
  • treatment indication
  • very elderly

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • B Whisenant

  • K Jones

  • K D Horton

  • S Horton

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free