Device closure of paravalvular defects following transcatheter aortic valve replacement with the Edwards Sapien valve.

  • B. W
  • K. J
  • K.D. H
 et al. 
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Paravalvular aortic insufficiency (AI) is observed in the majority of patients undergoing transcatheter aortic valve replacement (TAVR). While paravalvular AI is most commonly modest following TAVR, moderate or severe AI was seen in 10.5% and 6.8% of the PARTNER inoperable and high-risk cohorts at 1 year and has been reportedly associated with dyspnea and diminished survival. We report two cases of transcatheter heart valve (THV) associated paravalvular defects closed using catheter delivered devices. Both patients derived hemodynamic and symptomatic improvement from device closure. Additional research is warranted to define the adverse consequences of THV associated AI, indications for treatment, and risks associated with device closure of these defects. Copyright 2012 Wiley Periodicals, Inc.

Author-supplied keywords

  • *Aortic Valve Insufficiency/th [Therapy]
  • *Cardiac Catheterization/is [Instrumentation]
  • *Heart Valve Prosthesis
  • *Heart Valve Prosthesis Implantation/is [Instrumen
  • *aorta valve disease/su [Surgery]
  • *percutaneous aortic valve
  • *transcatheter aortic valve implantation
  • 80 and over
  • Aged
  • Aortic Valve Insufficiency/di [Diagnosis]
  • Aortic Valve Insufficiency/et [Etiology]
  • Aortic Valve Insufficiency/pp [Physiopathology]
  • Aortography
  • Cardiac Catheterization/ae [Adverse Effects]
  • Color
  • Doppler
  • Echocardiography
  • Female
  • Heart Valve Prosthesis Implantation/ae [Adverse Ef
  • Heart Valve Prosthesis Implantation/mt [Methods]
  • Hemodynamics
  • Humans
  • Male
  • New York Heart Association class
  • Prosthesis Design
  • Transesophageal
  • Treatment Outcome
  • aged
  • aorta root
  • aorta valve regurgitation/su [Surgery]
  • article
  • case report
  • catheter
  • cohort analysis
  • disease association
  • disease severity
  • dyspnea
  • guide wire
  • heart ejection fraction
  • heart hemodynamics
  • high risk patient
  • human
  • male
  • survival
  • transesophageal echocardiography
  • treatment indication
  • very elderly

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  • Whisenant B.

  • Jones K.

  • Horton K.D.

  • Horton S.

  • Brian Whisenant

  • Kent Jones

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