Diabetes and bone health

  • Antonopoulou M
  • Bahtiyar G
  • Ann M
 et al. 
  • 18


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


The increasing prevalence of diabetes especially type 2 diabetes worldwide is indisputable. Diabetics suffer increased morbidity and mortality, compared to their non-diabetic counterparts, not only because of vascular complications, but also because of an increased fracture incidence. Both types 1 and 2 diabetes and some medications used to treat it are associated with osteoporotic fractures. The responsible mechanisms remain incompletely elucidated. In this review, we evaluate the role of glycemic control in bone health, and the effect of anti-diabetic medications such as thiazolidinediones, sulfonylureas, DPP-4 inhibitors, and GLP-1 agonists. In addition, we examine the possible role of insulin and metformin as anabolic agents for bone. Lastly, we identify the current and future screening tools that help evaluate bone health in diabetics and their limitations. In this way we can offer individualized treatment, to the at-risk diabetic population. © 2013 Elsevier Ireland Ltd.

Author-supplied keywords

  • Diabetes
  • Fractures
  • Osteoporosis
  • Thiazolidinediones

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in


  • Marianna Antonopoulou

  • Gül Bahtiyar

  • Mary Ann

  • Alan S. Sacerdote

  • Mary Ann Banerji

  • Alan S. Sacerdote

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free