Diagnosis and treatment of primary CNS lymphoma in immunocompetent patients: guidelines from the European Association for Neuro-Oncology

  • Khê H
  • Bessell E
  • Bromberg J
 et al. 
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Abstract

The management of primary {CNS} lymphoma is one of the most controversial topics in neuro-oncology because of the complexity of the disease and the very few controlled studies available. In 2013, the European Association of {Neuro-Oncology} created a multidisciplinary task force to establish evidence-based guidelines for immunocompetent adults with primary {CNS} lymphoma. In this Review, we present these guidelines, which provide consensus considerations and recommendations for diagnosis, assessment, staging, and treatment of primary {CNS} lymphoma. Specifically, we address aspects of care related to surgery, systemic and intrathecal chemotherapy, intensive chemotherapy with autologous stem-cell transplantation, radiotherapy, intraocular manifestations, and management of elderly patients. The guidelines should aid clinicians in their daily practice and decision making, and serve as a basis for future investigations in neuro-oncology.

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Authors

  • Hoang-Xuan Khê

  • Eric Bessell

  • Jacoline Bromberg

  • Andreas F Hottinger

  • Matthias Preusser

  • Roberta Rudà

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