The diagnostic accuracy of fecal calprotectin during the investigation of suspected pediatric inflammatory bowel disease

  • Henderson P
  • Casey A
  • Lawrence S
 et al. 
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Abstract

OBJECTIVES: Fecal calprotectin (FC) is elevated in patients with inflammatory bowel disease (IBD). Studies evaluating FC during the initial investigation of children with suspected IBD have been limited, especially with regard to their small patient groups. We aimed to evaluate the diagnostic accuracy of FC in a large regional cohort of children undergoing full upper and lower endoscopy for suspected IBD, comparing FC with six common blood parameters. METHODS: Using a retrospective case-control design all FC measurements carried out between 2005 and 2010 in children

Author-supplied keywords

  • Adolescent
  • Biomarkers/analysis
  • C-Reactive Protein/analysis
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Colitis, Ulcerative/diagnosis/metabolism
  • Crohn Disease/diagnosis/metabolism
  • Diagnosis, Differential
  • Feces/chemistry
  • Female
  • Humans
  • Inflammatory Bowel Diseases/diagnosis/metabolism
  • Leukocyte L1 Antigen Complex/analysis
  • Male
  • Multivariate Analysis
  • Predictive Value of Tests
  • ROC Curve
  • Retrospective Studies
  • Severity of Illness Index
  • Time Factors

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Authors

  • P Henderson

  • A Casey

  • S J Lawrence

  • N A Kennedy

  • K Kingstone

  • P Rogers

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