Differences in lipid peroxidation and Cu,Zn-superoxide dismutase in the hippocampal CA1 region between adult and aged dogs.

  • Hwang I
  • Yoon Y
  • Yoo K
 et al. 
  • 8


    Mendeley users who have this article in their library.
  • 16


    Citations of this article.


Reactive oxygen species have been long associated with oxidative stress relevant to many pathological damages. In brain, 4-hydroxy-2E-nonenal (HNE), a major cytotoxic end product of lipid peroxidation, is produced. In contrast, superoxide dismutase (SOD), one of the major antioxidant enzymes, protects neurons from oxidative stress. The aim of this study is to observe differences in the distribution of HNE and Cu,Zn-superoxide dismutase (SOD1) in the hippocampal CA1 region of adult (2-3 years of age) and aged (10-12 years of age) dogs. The HNE immunoreactivity and protein level in the CA1 region were significantly high in the aged dogs compared to those in the adult dogs. SOD1 immunoreactivity and its protein level were also higher in the aged dogs than those in the adult dogs. However, there were not significant differences in NeuN (a neuron-specific soluble nuclear antigen) immunoreactivity in CA1 neurons between the adult and aged dogs. These differences may be associated with oxidative stress in aged dogs compared to that in adult dogs.

Author-supplied keywords

  • Age Factors
  • Aldehydes
  • Aldehydes: metabolism
  • Animals
  • Blotting
  • Dogs
  • Hippocampus
  • Hippocampus: metabolism
  • Hippocampus: physiology
  • Korea
  • Lipid Peroxidation
  • Lipid Peroxidation: physiology
  • Oxidative Stress
  • Oxidative Stress: physiology
  • Superoxide Dismutase
  • Superoxide Dismutase: metabolism
  • Western

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text


  • In Koo Hwang

  • Yeo Sung Yoon

  • Ki-Yeon Yoo

  • Hua Li

  • Jung Hoon Choi

  • Dae Won Kim

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free