Differences in skeletal muscle between men and women with chronic heart failure.

  • Duscha B
  • Annex B
  • Keteyian S
 et al. 
  • 1

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

Men with chronic heart failure (CHF) have alterations in their skeletal muscle that are partially responsible for a decreased exercise tolerance. The purpose of this study was to investigate whether skeletal muscle alterations in women with CHF are similar to those observed in men and if these alterations are related to exercise intolerance. Twenty-five men and thirteen women with CHF performed a maximal exercise test for evaluation of peak oxygen consumption (VO(2)) and resting left ventricular ejection fraction, after which a biopsy of the vastus lateralis was performed. Twenty-one normal subjects (11 women, 10 men) were also studied. The relationship between muscle markers and peak VO(2) was consistent for CHF men and women. When controlling for gender, analysis showed that oxidative enzymes and capillary density are the best predictors of peak VO(2.) These results indicate that aerobically matched CHF men and women have no differences in skeletal muscle biochemistry and histology. However, when CHF groups were separated by peak exercise capacity of 4.5 metabolic equivalents (METs), CHF men with peak VO(2) >4.5 METs had increased citrate synthase and 3-hydroxyacyl-CoA dehydrogenase compared with CHF men with peak VO(2)

Author-supplied keywords

  • Capillaries
  • Capillaries: pathology
  • Cardiac Output
  • Chronic Disease
  • Citrate (si)-Synthase
  • Citrate (si)-Synthase: metabolism
  • Enoyl-CoA Hydratase
  • Enoyl-CoA Hydratase: metabolism
  • Exercise Test
  • Female
  • Humans
  • Low
  • Low: metabolism
  • Low: pathology
  • Low: physiopathology
  • Male
  • Middle Aged
  • Muscle
  • Oxygen Consumption
  • Physical Endurance
  • Sex Characteristics
  • Skeletal
  • Skeletal: blood supply
  • Skeletal: enzymology
  • Skeletal: metabolism
  • Skeletal: pathology
  • Stroke Volume

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Brian D Duscha

  • Brian H Annex

  • Steven J Keteyian

  • Howard J Green

  • Martin J Sullivan

  • Gregory P Samsa

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free