Differential distribution of NAA and NAAG in human brain as determined by quantitative localized proton MRS

  • Pouwels P
  • Frahm J
  • 31

    Readers

    Mendeley users who have this article in their library.
  • 115

    Citations

    Citations of this article.

Abstract

Quantitative proton magnetic resonance spectroscopy was performed in frontal, parietal and occipital white and gray matter of young adults with use of a fully relaxed, short-echo time stimulated echo acquisition mode localization sequence at 2.0 T. Separate concentrations of the neuronal compounds N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) were obtained by user-independent spectral analysis (LCModel). Except for occipital gray matter in which an NAA concentration of 10.1 +/- 1.0 mM correlated with enhanced neuronal density in visual cortex, NAA was found to be homogeneously distributed throughout cortical white and gray matter at a concentration of 8.0-8.9 mM. NAAG concentrations of 1.5-2.7 mM were higher in white matter than levels of 0.6-1.5 mM found in gray matter, contributing up to 25% of total N-acetyl-containing compounds. The frontal to parieto-occipital increase of both gray and white matter NAAG levels is also reflected in the distribution of total NAA.

Author-supplied keywords

  • Human brain
  • N-acetylaspartate
  • N-acetylaspartylglutamate
  • Proton spectroscopy

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text

Authors

  • P. J W Pouwels

  • Jens Frahm

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free