Differential regulation of glucocorticoid receptor messenger RNA (GR-mRNA) by maternal deprivation in immature rat hypothalamus and limbic regions

  • Avishai-Eliner S
  • Hatalski C
  • Tabachnik E
 et al. 
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Maternal deprivation (MDep) of neonatal rats significantly influences the hypothalamic–pituitary– adrenal (HPA) axis. This study hypothesized that GR-mRNA modulation constituted an early, critical mechanism for the acute effects of MDep on neuroendocrine stress-responses. GR-mRNA hybridization signal in hippocampal CA1, hypothalamic paraventricular nucleus (PVN) and frontal cortex was significantly reduced immediately following 24 h MDep. In amygdala, cingulate cortex, PVN and CA1, apparent gender-dependent MDep effects on GR-mRNA expression were observed, without significant differences in absolute levels. Thus, rapid, region- specific MDep effects on GR-mRNA expression in HPA-regulating areas are shown, consistent with involvement of GR-expression in mechanisms of MDep influence on HPA tone. Keywords

Author-supplied keywords

  • 14 in the rat
  • 3
  • amygdala central nucleus
  • are characterized by altered
  • glucocorticoid receptor messenger rna
  • hippocampus
  • hypothalamic paraventricular nucleus
  • maternal deprivation
  • pnd
  • rat
  • stress
  • stress-responses during postnatal days

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  • Sarit Avishai-Eliner

  • Carolyn G. Hatalski

  • Elvan Tabachnik

  • Mariam Eghbal-Ahmadi

  • Baram Tallie Z.

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