Differential susceptibility of subsarcolemmal and intermyofibrillar mitochondria to apoptotic stimuli

  • Adhihetty P
  • Ljubicic V
  • Menzies K
 et al. 
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Apoptosis can be evoked by reactive oxygen species (ROS)-induced mitochondrial release of the proapoptotic factors cytochrome c and apoptosis-inducing factor (AIF). Because skeletal muscle is composed of two mitochondrial subfractions that reside in distinct subcellular regions, we investigated the apoptotic susceptibility of subsarcolemmal (SS) and intermyofibrillar (IMF) mitochondria. SS and IMF mitochondria exhibited a dose-dependent release of protein in response to H2O2 (0, 25, 50, and 100 microM). However, IMF mitochondria were more sensitive to H2O2 and released a 2.5-fold and 10-fold greater amount of cytochrome c and AIF, respectively, compared with SS mitochondria. This finding coincided with a 44{%} (P {

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  • Peter J. Adhihetty

  • Vladimir Ljubicic

  • Keir J. Menzies

  • David A. Hood

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