Differentiating the pathologies of cerebral malaria by postmortem parasite counts

  • Taylor T
  • Fu W
  • Carr R
 et al. 
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Abstract

To study the pathogenesis of fatal cerebral malaria, we conducted autopsies in 31 children with this clinical diagnosis. We found that 23% of the children had actually died from other causes. The remaining patients had parasites sequestered in cerebral capillaries, and 75% of those had additional intra- and perivascular pathology. Retinopathy was the only clinical sign distinguishing malarial from nonmalarial coma. These data have implications for treating malaria patients, designing clinical trials and assessing malaria-specific disease associations.

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Authors

  • Terrie E. Taylor

  • Wenjiang J. Fu

  • Richard A. Carr

  • Richard O. Whitten

  • Jeffrey G. Mueller

  • Nedson G. Fosiko

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