To study the pathogenesis of fatal cerebral malaria, we conducted autopsies in 31 children with this clinical diagnosis. We found that 23% of the children had actually died from other causes. The remaining patients had parasites sequestered in cerebral capillaries, and 75% of those had additional intra- and perivascular pathology. Retinopathy was the only clinical sign distinguishing malarial from nonmalarial coma. These data have implications for treating malaria patients, designing clinical trials and assessing malaria-specific disease associations.
CITATION STYLE
Taylor, T. E., Fu, W. J., Carr, R. A., Whitten, R. O., Mueller, J. G., Fosiko, N. G., … Molyneux, M. E. (2004). Differentiating the pathologies of cerebral malaria by postmortem parasite counts. Nature Medicine, 10(2), 143–145. https://doi.org/10.1038/nm986
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