Diffusion Tensor Imaging (DTI) identifies deficits in white matter microstructure in subjects with type 1 diabetes mellitus that correlate with reduced neurocognitive function

  • Kodl C
  • Franc D
  • Rao J
 et al. 
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Abstract

Objective: Long-standing type 1 diabetes mellitus is associated with deficits on neurocognitive testing that suggest central white matter dysfunction. This study investigated whether diffusion tensor imaging, a type of magnetic resonance imaging that measures white matter integrity quantitatively, could identify white matter microstructural deficits in patients with long standing type 1 diabetes and whether these differences would be associated with deficits found by neurocognitive tests. Research Design and Methods: 25 subjects with type 1 diabetes for at least 15 years and 25 age- and gender-matched control subjects completed diffusion tensor imaging on a 3.0 Tesla scanner and a battery of neurocognitive tests. Fractional anisotropy was calculated for the major white matter tracts of the brain. Results: Subjects with diabetes had significantly lower mean fractional anisotropy than control subjects in the posterior corona radiata and the optic radiation (p

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Authors

  • C.T. Kodl

  • D.T. Franc

  • J.P. Rao

  • F.S. Anderson

  • W. Thomas

  • B.a. Mueller

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