Diffusion tensor MRI of the corpus callosum and cognitive function in adults born preterm

  • Kontis D
  • Catani M
  • Cuddy M
 et al. 
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Very preterm birth (before 33 weeks gestation) is associated with the white matter damage, and a common sequel is reduced size and altered shape of the corpus callosum. We used diffusion tensor MRI to assess the corpus callosum in 63 very preterm and 45 term-born young adults. Indices of white matter microstructure [fractional anisotropy (FA) and mean diffusivity (MD)] were obtained for the genu, body and splenium. Very preterm females had higher MD in the genu than term-born females, indicating altered white matter microstructure. This was associated with lower performance IQ. The groups demonstrated different patterns of correlations between verbal learning and tract-specific FA and MD, consistent with the reorganization of white matter structure in adults born very preterm.

Author-supplied keywords

  • Adolescent
  • Anisotropy
  • Cognition
  • Corpus Callosum/ anatomy & histology/ physiology
  • Diffusion Magnetic Resonance Imaging
  • Female
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Intelligence/physiology
  • Learning/physiology
  • Male
  • Sex Characteristics
  • Young Adult

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  • D Kontis

  • M Catani

  • M Cuddy

  • M Walshe

  • C Nosarti

  • D Jones

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