Diffusion-weighted magnetic resonance imaging in the diagnosis of bone tumors: Preliminary results

  • Y. P
  • M. K
  • A. K
  • 1


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Objective: The study aims to determine whether apparent diffusion coefficient (ADC) can help differentiate benign and malignant bone tumors. Materials and Methods: From January 2012 to February 2013, we prospectively included 26 patients. Of these 15 patients were male and 11 were female; ranging in age from 8 to 76 years (mean age, 34.5 years). Diffusion-weighted magnetic resonance (MR) imaging was obtained with a single-shot echo-planar imaging sequence using a 1.5T MR scanner. We grouped malignant lesions as primary, secondary, and primary tumor with chondroid matrix. The minimum ADC was measured in the tumors and mean minimum ADC values were selected for statistical analysis. ADC values were compared between malignant and benign tumors using the Mann-Whitney U-test and receiver operating curve analysis were done to determine optimal cut-off values. Results: The mean ADC values from the area with lowest ADC values of benign and malignant tumors were 1.99 ± 0.57 × 10-3 mm 2/s and 1.02 ± 1.0 × 10 -3 mm 2/s, respectively. The mean minimum ADC values of benign and malignant tumors were statistically different (P = 0.029). With cut-off value of 1.37 (10-3 mm 2/s), sensitivity was 77.8% and specificity was 82.4%, for distinguishing benign and malignant lesion. Benign and secondary malignant tumors showed statistically significant difference (P = 0.002). There was some overlap in ADC values between benign and malignant tumors. The mean minimum ADC values of benign and malignant chondroid tumors were high. Giant cell tumor, non-ossifying fibroma and fibrous dysplasia showed lower ADC values. Conclusion: Although there is some overlap, ADC values of benign and malignant bone tumors seem to be different. Further studies with larger patient groups are needed to find an optimal cut-off ADC value.

Author-supplied keywords

  • Ewing sarcoma
  • adult
  • aged
  • aneurysmal bone cyst
  • article
  • bone cyst
  • bone marrow
  • bone tumor
  • breast cancer
  • cancer diagnosis
  • child
  • chondroblastoma
  • chondrosarcoma
  • clinical article
  • cortical bone
  • diagnostic test accuracy study
  • diffusion weighted imaging
  • echo planar imaging
  • enchondroma
  • female
  • fibrous dysplasia
  • giant cell tumor
  • human
  • image analysis
  • image enhancement
  • kidney cancer
  • lung adenocarcinoma
  • male
  • malignant neoplasm
  • middle aged
  • nuclear magnetic resonance scanner
  • ossifying fibroma
  • osteoblastoma
  • osteosarcoma
  • priority journal
  • prospective study
  • prostate cancer
  • school child
  • sensitivity and specificity
  • young adult

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Pekcevik Y.

  • Kahya M.

  • Kaya A.

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free