Directed stem cell differentiation: The role of physical forces

  • Clause K
  • Liu L
  • Tobita K
  • 89


    Mendeley users who have this article in their library.
  • 26


    Citations of this article.


A number of factors contribute to the control of stem cell fate. In particular, the evidence for how physical forces control the stem cell differentiation program is now accruing. In this review, the authors discuss the types of physical forces: mechanical forces, cell shape, extracellular matrix geometry/properties, and cell-cell contacts and morphogenic factors, which evidence suggests play a role in influencing stem cell fate.

Author-supplied keywords

  • Cell shape
  • Cell-cell contacts
  • Differentiation
  • ECM properties
  • Geometric controls
  • Mechanical force
  • Morphogenic factors

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Kelly C. Clause

  • Li J. Liu

  • Kimimasa Tobita

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free