The Directed Synthesis of Biaryl Compounds: Modern Concepts and Strategies

  • Bringmann G
  • Walter R
  • Weirich R
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The preparation and utilization of specific biaryl systems, particularly
those which suffer hindered rotation, is a demanding goal not only
in the synthesis of natural products and Pharmaceuticals, but also
for example in the discovery of new reagents for asymmetric synthesis.
This article will attempt to provide a topical review of modern,
efficient processes for the specific preparation of biaryls. This
appears to be of particular urgency, since, under the pressure of
continually increasing demand, a wealth of new or modified synthetic
approaches to the ever more important biaryl systems has been realized
in recent years. The high standard which has been reached in this
field is impressively demonstrated by regio- and stereoselective
syntheses of important biaryl natural products such as steganone,
ancistrocladine, ancistrocladisine, and dioncophylline A. Besides
the utilization of asymmetric induction in the actual coupling step,
the thermodynamically or kinetically controlled torsion of biaryl
axes belongs to the most important concepts discussed.

Author-supplied keywords

  • Arenes
  • Asymmetric synthesis
  • Biaryls
  • Synthetic methods

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