Directionality of kinesin motors

  • Kasprzak A
  • Hajdo Ł
  • 20


    Mendeley users who have this article in their library.
  • 8


    Citations of this article.


Kinesins are molecular motors that transport various cargoes along microtubule tracks using energy derived from ATP hydrolysis. Although the motor domains of kinesins are structurally similar, the family contains members that move on microtubules in opposite directions. Recent biochemical and biophysical studies of several kinesins make it possible to identify structural elements responsible for the different directionality, suggesting that reversal of the motor movement can be achieved through small, local changes in the protein structure.

Author-supplied keywords

  • ATP
  • Force-generation
  • Kinesin
  • Microtubule
  • Molecular motor
  • Movement
  • Mutation
  • X-ray crystallography
  • ncd

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Andrzej A. Kasprzak

  • Łukasz Hajdo

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free