Discovering the mechanisms of neurodegeneration in prion diseases

  • DeArmond S
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Abstract

The purpose of my chapter in this issue of Neuroscience Reviews dedicated to Dr. Lawrence Eng is to summarize my contributions to understanding the mechanisms of neurodegeneration in prion diseases. I explain that I was able to advance the field of prion disease neuropathology largely because of the foundation of neurochemistry and immunohistochemistry that I learned while working 5 years in Dr. Eng's laboratory. In my review, I relate how my Neuropathology Research Laboratory began as a collaboration with Dr. Stanley Prusiner 20 years ago that led from immunohistochemical staining of amyloid plaques in rodent and human brains using prion protein-specific antibodies to molecular evidence that the abnormal prion protein, PrPSc, is the cause of the clinically relevant neuropathological changes in animal and human prion diseases

Author-supplied keywords

  • AMYLOID PLAQUES
  • Antibodies
  • BRAIN
  • Bovine Spongiform Encephalopathy
  • CREUTZFELDT-JAKOB DISEASE
  • CREUTZFELDT-JAKOB-DISEASE
  • CULTURED-CELLS
  • DISEASE
  • DISEASES
  • EXPERIMENTAL SCRAPIE
  • FIBRILLARY ACIDIC PROTEIN
  • GERSTMANN-STRAUSSLER SYNDROME
  • Gerstmann-Straussler-Scheinker disease
  • HEPATIC-ENCEPHALOPATHY
  • Human
  • MECHANISM
  • NEURODEGENERATION
  • PATHOGENESIS
  • PRION DISEASE
  • PRION PROTEIN
  • PRION-PROTEIN
  • Prion Diseases
  • SCRAPIE
  • SEQUENTIAL DEVELOPMENT
  • TRANSGENIC MICE
  • amyloid
  • neuropathology
  • prion
  • protein
  • review

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Authors

  • S J DeArmond

  • S J DeArmond

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