Discovery of diaryl imidazolidin-2-one derivatives, a novel class of muscarinic M3 selective antagonists (Part 1)

  • Peretto I
  • Forlani R
  • Fossati C
 et al. 
  • 20

    Readers

    Mendeley users who have this article in their library.
  • 17

    Citations

    Citations of this article.

Abstract

Synthesis and biological activity of a novel class of quaternary ammonium salt muscarinic M3 receptor antagonists, showing high selectivity versus the M2 receptor, are described. Selected compounds exhibited potent anticholinergic properties, in isolated guinea-pig trachea, and good functional selectivity for trachea over atria. In vivo, the same compounds potently inhibited acetylcholine-induced bronchoconstriction after intratracheal administration in the guinea pig.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Ilaria Peretto

  • Roberto Forlani

  • Claudia Fossati

  • Giuseppe A M Giardina

  • Alessandra Giardini

  • Matilde Guala

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free