Discovery of diaryl imidazolidin-2-one derivatives, a novel class of muscarinic M3 selective antagonists (Part 1)

  • Peretto I
  • Forlani R
  • Fossati C
 et al. 
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Synthesis and biological activity of a novel class of quaternary ammonium salt muscarinic M3 receptor antagonists, showing high selectivity versus the M2 receptor, are described. Selected compounds exhibited potent anticholinergic properties, in isolated guinea-pig trachea, and good functional selectivity for trachea over atria. In vivo, the same compounds potently inhibited acetylcholine-induced bronchoconstriction after intratracheal administration in the guinea pig.

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  • Ilaria Peretto

  • Roberto Forlani

  • Claudia Fossati

  • Giuseppe A M Giardina

  • Alessandra Giardini

  • Matilde Guala

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