From Discrete Protein Kinetics to Continuous Brownian Dynamics: A New Perspective

  • Qian H
  • 37


    Mendeley users who have this article in their library.
  • 25


    Citations of this article.


An analysis on the discrete versus continuous views of kinetics of macromolecules is presented. It is shown that the discrete approach traditional to biochemistry is insufficient for understanding the dynamics of protein molecules in aqueous solution. A continous view based on the Brownian dynamics in energy landscape offers a more comprehensive description of the biological macromolecules. Two examples, one on protein folding and one on channel gating, are discussed.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Hong Qian

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free