Diversity of metabolic shift in response to oxygen deprivation in Corynebacterium glutamicum and its close relatives

  • Yamamoto S
  • Sakai M
  • Inui M
 et al. 
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Abstract

Oxygen-deprived Corynebacterium glutamicum R cells remain metabolically active, producing considerable amounts of organic acids even when not actively growing. We compared the proficiencies of C. glutamicum and close relatives grown under aerobic conditions to metabolize glucose when deprived of oxygen. Eight strains that readily consumed glucose without cell growth subsequently produced organic acids. Among these, the glucose consumption rates of the two C. glutamicum strains (>40 mM/h) and Corynebacterium efficiens (>12 mM/h) were an order of magnitude higher than those of the other five strains. The resultant organic acid yields of these three strains (>86%) consequently exceeded those of the other five (

Author-supplied keywords

  • Corynebacterium relatives
  • Glucose consumption
  • Metabolic shift
  • Organic acid production
  • Oxygen deprivation

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Authors

  • Shogo Yamamoto

  • Masayuki Sakai

  • Masayuki Inui

  • Hideaki Yukawa

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