The Dlk1 and Gtl2 genes are linked and reciprocally imprinted

  • Schmidt J
  • Matteson P
  • Jones B
 et al. 
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Abstract

Genes subject to genomic imprinting exist in large chromosomal domains, probably reflecting coordinate regulation of the genes within a cluster. Such regulation has been demonstrated for the H19, Igf2, and Ins2 genes that share a bifunctional imprinting control region. We have identified the Dlk1 gene as a new imprinted gene that is paternally expressed. Furthermore, we show that Dlk1 is tightly linked to the maternally expressed Gtl2 gene. Dlk1 and Grl2 are coexpressed and respond in a reciprocal manner to loss of DNA methylation. These genes are likely to represent a new example of coordinated imprinting of linked genes.

Author-supplied keywords

  • Dlk1
  • Genomic imprinting
  • Gtl2

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Authors

  • Jennifer V. Schmidt

  • Paul G. Matteson

  • Beverly K. Jones

  • Xiao Juan Guan

  • Shirley M. Tilghman

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